Dropper automatically fills upon opening tightly-closed cap. Release a dropper-full⁺ of serum into your palm and smooth evenly over face. Re-close cap tightly after each use, taking care not to press down on the rubber dropper head. ⁺A single pump of the dropper will give you the optimal dosage. Manually refill by pushing down on the rubber dropper head if more serum is desired. Use twice a day, morning and night.