Use at any time of the day and as often as necessary. • Massage a small amount onto the backs and palms of your hands with large circular motions. 2 minutes of gentle massage will allow the cream to penetrate the upper layers of your skin for immediate comfort. • Take time to work the formula into your fingers, over your knuckles, and on the dry areas between your fingers. • With any remaining cream, massage into each finger, from the top of the knuckle down to the ends of your fingertips.